Synthesis of a new family of acyclic nucleoside phosphonates, analogues of TPases transition states.
نویسندگان
چکیده
A 6-step procedure was developed for the synthesis of a new family of acyclic nucleoside phosphonates (ANPs), "PHEEPA" [(2-pyrimidinyl-2-(2-hydroxyethoxy)ethyl)phosphonic acids] in overall yields ranging from 4.5% to 32%. These compounds, which possess on one side a hydroxy function and on the other side a phosphonate group, can be considered either as potential antiviral agents or as transition state analogues of nucleoside phosphorylases such as thymidine phosphorylase.
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 10 17 شماره
صفحات -
تاریخ انتشار 2012